1) Diabetes People with diabetes typically make frequent trips to the restroom, part of the process of ridding extra glucose via urination. They should remain more mindful of consuming more fluids to make up for the loss. 2) PMS Robert Kominiarek, DO, a family physician explains that PMS alters hormones like estrogen and progesterone, an in turn, affect hydration levels. Furthermore, women with a very heavy blood flow during this time are likely losing more water. 3) Stress It’s not easy to escape, but stress is another surprising factor that can cause dehydration. The bottom line is that too much of it activates stress hormones, part of a detailed process in the body that ultimately impacts electrolyte and fluid levels. 4) Not enough fruits and vegetables Because these foods tend to have a high water content, not incorporating enough in diets can lead to dehydration.